Stability engineering of scFvs for the development of bispecific and multivalent antibodies

Brian R.Miller1,5, Stephen J.Demarest1, Alexey Lugovskoy2, Flora Huang1, Xiufeng Wu1, William B.Snyder1, Lisa J.Croner3, Norman Wang4, Aldo Amatucci2, Jennifer S.Michaelson2 and Scott M.Glaser1 Biogen Idec, Inc., 5200 Research Place, San Diego, CA 92122, USA, Biogen Idec, Inc., 12 Cambridge Center, Cambridge, MA 02142, UK, Present address: Biosite Inc., 9975 Summers Ridge Road, San Diego, CA 92121, USA and Present address: Molecular Biosciences and Bioengineering, University of Hawaii-Manoa, 1955 East-West Road, Ag. Science 218, Honolulu, HI 96822, USA