Statistical power and significance testing in large-scale genetic studies

Pak C. Sham,Shaun Purcell

Statistical power and significance testing in large-scale genetic studies

2014

Pak C. Sham
Shaun Purcell

This Review discusses the principles and applications of significance testing and power calculation, including recently proposed gene-based tests for rare variants.

Keywords:

Genetics
Bioinformatics
Biology
Statistical power
Gene
Genome-wide association study
significance testing

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