Tartaric Acid Synthetic Derivatives for Multi-Drug Resistant Phytopathogen Pseudomonas and Xanthomonas Combating

The resistance to antimicrobial preparations, according the WHO reports of recent years, is becoming the one of the most actual healthcare problems of this century. Nevertheless, the key role of antibiotics diversity increase, as well as the increase of their application scopes, the initial origin of antimicrobial resistance problem is the versatility of adaptation mechanisms potential of all microorganisms, including intraspecific gene horizontal transfer and quorum sensing. Thus, the actuality of search of new, ecologically safe and harmless for human health antimicrobial agents, among the natural and semisynthetic compounds, is being significantly increased. One of the prospective directions in these research is the derivatization of aldaric acids, isolated from plants different species, as the native antibacterial active substances, such as like: citric, acetic, tartaric, lactic.   In current research, 7 new derivatives of natural tartaric acid (TA): cyclohexylimide, benzylimide, phenylimide, benzyl mono amino salt, cyclohexyl mono amino salt, phenyl amino salt and mono ethanol amino salt of TA were tested on different strains from 6 subtypes of 3 species of phytopathogenic multi-drug resistant Xanthomonas and Pseudomonas. During the research it was detected the significant antimicrobial effect of studied compounds against the range of phytopathogens which are resistant to antibiotics from different classes and generations (ciprofloxacin, chloramphenicol, ceftriaxone, azithromycin, etc.). It was detected the higher efficiency of cyclohexyl- derivatives in comparison with mono ethanol-, phenyl- and benzyl- derivatives.