Anxiolytic - like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2 - methy

3-Aminoalkyl-4-aryl-1,5,6,7-tetrahydro-2H-azepines, e.g. those of the formula Ar' = phenyl, thienyl, pyridyl or phenyl subst. by alkyl, alkoxy, alkylthio, halo or CF3; Am' = NH2, (alkyl, alkenyl, alkynyl, hydroxyalkyl, cycloalkyl, or benzyl)amino, its N-lower alkyl derivatives; alkyleneimino, morpholino or piperazino; q = 0 or 1; X = H2 or 0; R', R'' = H or alkyl; and salts thereof are potassium-sparing diuretic agents.