Fragment-based labeling using condensation reactions of six potential 5-HT 7 R PET tracers
2020
In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six 18F-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development of a 5-HT7R PET tracer. They were radiolabeled in sufficient radiochemical yields, purities and molar activities for future in vivo evaluation in rodents.
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