Sarcopenia associated with renal function in the patients with type 2 diabetes

Abstract Aims Studies have suggested that low muscle mass is associated with declining renal function in healthy populations, whether the association is relevant to patients with type 2 diabetes is not well understood. This study investigates the association between sarcopenia and estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratios (UACR) in the patients with type 2 diabetes. Methods Two recruited groups consisted of 793 persons without diabetes (males/females = 550/243) and 762 persons with type 2 diabetes (males/females = 501/261). Results The non-sarcopenia population demonstrated higher ASM/HT 2 , GFR ( P P  ＜ 0.05) than the sarcopenia population. In studied men, the association between ASM/HT 2 and eGFR was statistically significant in the group without diabetes (OR = 0.580, P  = 0.020), a trend which persisted in women (OR = 0.491, P  = 0.014). The association between ASM/HT 2 and UACR persisted in studied women of two groups (OR = 0.269, P  = 0.005; OR = 0.405, P  = 0.008, respectively). The highest quartile of ASM/HT 2 in the non-sarcopenia population exhibited a 3.753-fold risk of abnormal eGFR within the diabetes group (OR = 3.753, P  = 0.020). The cutoff point of ASM/HT 2 to indicate abnormal renal function for population with non-sarcopenia was 6.32 kg/m 2 in the group without diabetes and 6.31 kg/m 2 in diabetes group. Conclusions Sarcopenia is associated with declining renal function, which induces lower eGFR and higher UACR. In the non-sarcopenia population, ASM/HT 2 presents as renal function risk factor, which perhaps associated with higher muscle mass to induce a greater underestimation for creatinine and urinary albumin.