Effect of Different Substituted Position of Phenylcarbamoyl‐β‐CD on the Enantioseparation of Drugs by Capillary Electrophoresis

ABSTRACT A number of acidic and basic chiral drugs such as β‐agonists, β‐antagonists, and phenylethylamines were separated by capillary electrophoresis with mono‐3‐O‐phenylcarbamoyl‐β‐CD and mono‐6‐O‐phenylcarbamoyl‐β‐CD. The effects of the CD type and concentration and the pH of the background electrolyte on the resolution of the drugs had been studied. The substituted position has a significant effect on the separation of chiral drugs and is therefore an important factor in the optimization of chiral resolution. Accordingly, a proper description of derived cyclodextrins should include substituted position.