Kinetics and Mechanistic Study of Oxidation of Atenolol Drug in Acidic Medium by 12-Tungstocobaltate(III)

The kinetics of oxidation of atenolol by 12-tungstocobaltate (III) in aquous acidic medium at a constant ionic strength of 0.25 mol dm -3 was studied spectrophotometrically at λmax 624nm under pseudo first order conditions. The reaction between atenolol and 12-tungstocobaltate (III) in acidic medium exhibits 1:2 stoichiometry [atenolol:12-tungstocobaltate (III)]. The main oxidative products were identified by TLC spot test, FT-IR studies. The effect of [H + ] ion, [Cl - ] ion and ionic strength of the reaction medium have been investigated. The reaction constants involved in the different steps of the mechanism are calculated. The activation parameter with respect to slow step of the mechanism are computed and discussed. The thermodynamic parameters of the rate-determining steps were evaluated. A mechanism related to this reaction is proposed.