Histiocitosis, una visión práctica para el dermatólogo

Histiocytosis comprises a broad group of disorders characterized by abnormal clonal proliferation of histiocytes in different tissues. Clinical manifestations may be limited to the skin and can even be the first sign of the disease, or they may be accompanied by systemic involvement as in most cases. Classification has been complex and controversial through history, the simplest way to approach divides these in Langerhans cell and non-Langerhans cell histiocytosis and malignant histiocytosis. A review of benign histiocytic disorders from the immunohistochemical approach with the most relevant clinical aspects useful for dermatological practice is presented.