Oxidative Remote C—H Trifluoromethylation of Quinolineamides on the C5 Position with Iodobenzene Diacetate as the Oxidizing Agent.

A facile, metal-free protocol has been developed for the remote trifluoromethylation of 8-aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8-aminoquinolineamides reacted with an inexpensive and commercially available CF3 source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.