Highly Diastereo‐ and Enantioselective Construction of a Spiro[cyclopenta[b]indole‐1,3′‐oxindole] Scaffold via Catalytic Asymmetric Formal [3 + 2] Cycloadditions.

An organocatalytic asymmetric formal [3+2] cycloaddition of isatin-derived 3-indolylmethanol with 3-methyl-2-vinylindole has been established, leading to highly stereoselective construction of a spiro[cyclopenta[b]indole-1,3′-oxindole] scaffold with the concomitant creation of three contiguous stereogenic centers (72–99% yield, all >95 : 5 dr, 90–98% ee), one of which is an all-carbon quaternary stereogenic center.