Studies on technetium-99m-labelled monophosphonates: 1,2-Epoxypropylphosphonic acid and its hydrolysed form

Abstract 1,2-Epoxypropylphosphonic acid (fosfomycin) when labelled with 99m Tc at pH = 6.8 was described as a renal imaging agent. Under the same experimental conditions, except pH = 2.5, 99m Tc fosfomycin has shown bone uptake. The hydrolysed form of fosfomycin, the 1,2-dihydroxypropyl-1-phosphonic acid when labelled with 99m Tc in identical conditions, also has shown similar biological behaviour. Extraction and adsorption experiments conducted on both radiopharmaceuticals have shown that renal uptake preparations are Tc(V) complexes, meanwhile bone uptake preparations are Tc(IV) and/or Tc(III) complexes.