The Abluminal Endothelial Membrane in Neurovascular Remodeling in Health and Disease

Gloss The blood-brain barrier (BBB) can break down in response to brain injury, and stepwise restoration of its integrity occurs during subsequent neurovascular remodeling. In this Review, with 5 figures and 125 references, we outline the signaling processes at the abluminal endothelial membrane that contribute to the restitution of BBB integrity in the injured brain. A detailed understanding of these signaling events may yield new targets for pharmacological therapy of diseases associated with brain injury.