Circulating CX3CL1 in patients with liver cirrhosis

s / Journal of Clinical Virology 69 (2015) 223–246 229 the biophysical properties of infectious HCV particles were also changed by CiDeB silencing, compared with control. CiDeB silencing impairedassociationofAPOEwithHCVparticles, partly through disrupted NS5A-APOE interaction. We also showed that CiDeB was also required for assembly and/or release of dengue virus. Collectively, CiDeB, downstream of PGC-1 and HNF4 , contributes to the assembly step of HCV life cycle and interacts with HCV NS5A. Interpretation: These results suggest that CiDeB is a new host factor involved in HCV assembly, presumably by direct interaction with viral proteins. http://dx.doi.org/10.1016/j.jcv.2015.06.023