The implications of hypersomnia in the context of major depression: Results from a large, international, observational study

Abstract According to the DSM-5, “reduction in the need for sleep” is the only sleep-related criteria for mixed features in depressive episodes. We aimed at studying the prevalence, clinical correlates and the role of hypersomnia in a sample of acutely depressed patients. Secondarily, we factors significantly increasing the odds of hypersomnia were studied. We conducted a post-hoc analysis of the BRIDGE-II-Mix study. Variables were compared between patients with hypersomnia (SLEEP+) and with insomnia (SLEEP−) with standard bivariate tests. A stepwise backward logistic regression model was performed with SLEEP+ as dependent variable. A total of 2514 subjects were dichotomized into SLEEP+ ( n  = 423, 16.8%) and SLEEP− ( n  = 2091, 83.2%). SLEEP+ had significant higher rates of obese BMI ( p p  = 0.027), severe BD ( p p p  = 0.004) than SLEEP−. Also, SLEEP+ had significantly poorer response to antidepressants (AD) such as (hypo)manic switches, AD resistance, affective lability, or irritability (all 0