trimethylation of selectively altered PRC2 catalytic activity, to increase H3K27 Somatic mutations at EZH2 Y641 act dominantly through a mechanism

doi:10.1182/blood-2010-11-321208 Prepublished online Dec 29, 2010;2011 117: 2451-2459€€€€A. J. R. Aparicio Marra, Randy D. Gascoyne, R. Keith Humphries, Cheryl H. Arrowsmith, Gregg B. Morin and SamuelRyan D. Morin, Andrew J. Mungall, Barbara Meissner, Merrill Boyle, Victor E. Marquez, Marco A. Damian B. Yap, Justin Chu, Tobias Berg, Matthieu Schapira, S.-W. Grace Cheng, Annie Moradian,€