Meyer's loop asymmetry and language lateralisation in epilepsy

Objectives Several studies have suggested an asymmetry in Meyer9s loop in individuals, with the left loop anterior to the right. In this study we test the hypothesis that there is an association between Meyer9s loop asymmetry (MLA) and language lateralisation. Methods 57 patients with epilepsy were identified with language functional MRI (fMRI) and diffusion MRI acquisition. Language lateralisation indices from fMRI(LI) and optic radiation and arcuate fasciculus probabilistic tractography was performed for each subject. The subjects were divided into left language dominant (LI>0.4) and non-left language groups (LI Results A negative linear correlation was identified between language lateralisation and MLA, with greater left lateralised language associated with more anteriorly placed left Meyer9s loops (R value −0.34, p=0.01). There was a significant difference in mean MLA between the two groups, with the left loop being anterior to the right loop in the LI>0.4 group and posterior to the right loop in the LI Conclusions This study suggests an association between the extent of Meyer9s loop asymmetry and the lateralisation of language determined by fMRI in patients with epilepsy. Further studies should be carried out to evaluate this association in control subjects and with other measures of language lateralisation.