Development of ultrasensitive Doppler imaging method for the surgical management of open-brain tumors

Gliomas are infiltrating tumors in the healthy brain parenchyma with no clear boundaries and can be located near or within "functional" brain zones driving as an example, motor skills, sensitivity, cognition or vision. Two conflicting objectives must be achieved during cerebral glioma surgery: (1) to obtain a tumor excision as complete as possible, the oncological prognosis being improved by surgery; and (2) to limit the risk of definitive neurological deficit by respecting the brain areas infiltrated by the tumor remaining functional. The objective of our work is to develop an intraoperative biomecanical analysis and a micro vascularization imaging method and validate the interest of these techniques for the diagnosis of tumor neo-angiogenesis and ultimately to target the surgical procedure during surgery.