Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

. LMAN1 is a mannose-binding type 1 transmembrane protein localized to theendoplasmic reticulum–Golgi intermediate compartment(ERGIC; refs. 2,3), suggesting that F5F8D could result from adefect in secretion of factor V and factor VIII (ref. 4). Correctlyfolded proteins destined for secretion are packaged in the ERinto COPII-coated vesicles