Distribution and drug resistance of pathogens causing infective pneumonia in neonates of low birth weight

OBJECTIVE To explore the distribution and drug resistance of the pathogens causing infective pneumonia in neonates of low birth weight so as to guide the reasonable clinical use of antibiotics.METHODS A total of 69 patients who were treated in neonatal wards from Jan 2010to Jan 2013were selected in our hospital medicine in treatment of 69patients as the research objects,then the common species of pathogens causing infections were analyzed,and the drug resistance of the pathogens was observed by means of relevant test methods.RESULTS A total of 70strains of pathogens have been isolated,including 55(78.6%)strains of gram-negative bacteria,14(20.0%)strains of gram-positive bacteria,and 1(1.4%)strain of fungi;Klebsiella pneumoniae,Escherichia coli,Staphylococcus epidermidis,Enterobacter cloacae,and Acinetobacter baumannii ranked the top 5species of gram-negative pathogens,accounting for 30.0%,24.3%,14.3%,12.9%,and 11.4%,respectively;the gramnegative bacteria were highly susceptible to amikacin,imipenem,and levofloxacin but were highly resistant to cephalosporins,aminoglycosides,and penicillin;the gram-positive bacteria were significantly resistant to penicillin,and cephalosporins,and aminoglycosides and were only susceptible to teicoplanin,aitrofurantoin,and vancomycin.CONCLUSION Great attention should be paid to the bacteriologic test of the pathogens causing the infective pneumonia in the neonates of low birth weight;the clinical physicians should use antibiotics reasonably based on the result of identification of pathogens and the drug susceptibility testing.