Chemical composition, antibacterial screening and cytotoxic activity of Chiliadenus antiatlanticus (Emb. & Maire) Gómiz (Asteraceae) essential oil.

The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gomiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07 ± 0.28%, twenty-seven metabolites were identified representing more than 96% of the total composition. Camphor (35.7%) and derivatives, borneol (4.9%) and camphene (4.2%) together with intermedeol (19.9%), α-pinene (15.5%) and E-pinocarveol (4.1%) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values = 100 µg/mL. The EO also showed significant toxicity towards liver HepG2 (55.8% of cell viability) and melanoma B16 4A5 (41.6% of cell viability) tumor cell lines at 100 µg/mL.