The Rat (Rattus norvegicus) as a Model Object for Acute Organophosphate Poisoning. 2. A System Analysis of the Efficacy of Green Tea Extract in Preventing Delayed Effects of Poisoning

Studying the drugs of natural origin that promote recovery of an organism after acute poisoning with household and industrial toxicants, including organophosphates (OPs), is a challenge not only to toxicology but also informatics, which is a major tool for developing the methodology of system analysis. We report here the data on the effect of decaffeinated green tea extract (GTE) as a pelleted feed component on the dynamics of 12-week recovery of rats after acute paraoxon (POX) poisoning in the models with preliminary specific and nonspecific inhibition of blood plasma carboxylesterase. GTE causes a decrease in atherogenic indices and a positive dynamics in other combinatorial indices due to its effect on levels of hemoglobin, total protein, albumin, triacylglycerides, orosomucoid, and calcium ions as well as on the balance of immune cells. Thereby, GTE is supposed to promote regeneration of an organism after acute POX poisoning. The heuristic algorithm that we proposed previously to derive combinatorial markers by the branch and bound approach was optimized in this study, allowing us to increase the statistical significance of intergroup and/or temporal differences and to form syndromic complexes via clusterization of physiological and biochemical indices. The latter may considerably complement experimental studies conducted on different animal species and ensure more adequate interpretation of the resulting data as applied to humans.