Evaluation of Polymers as binder on Coprocess of tablet.

Evaluation of polymers as binder on coprocess tablet was prepared with hydroxypropyl methyl cellulose (HPMC), citric acid graft locust bean gum (CAgLBG), locust bean gum (LBG) and polyvinylpirrolidone K-30 (PVP K-30) as binder. Study aims to determine the physical quality of coprocess granules, tablets, and dissolution studies. Wet granulation method was used to create granules coprocess. Granules were evaluated for flow rate, angle of repose, granul density, tapped density, housner ratio, and carr’s index. Tablet were evaluated for thickness, hardness, friability, disintergrant time, and dissolution of tablet. All granules coprosses using variation binder were meet to standard of physical quality of granules and tablets. Tablets using binder LBG have drug release and ED60 are highest.