Tavşanlarda Borik Asidin Kan Kimyasına Etkisi

This study was carried out to investigate the influence of boric acid (BA) on blood chemistry in rabbits.Forty, 16 weeks old, New Zealand rabbits were assigned to 4 groups consisting of 10 rabbits in each group. Thegroups received the following treatment: group 1: control group without treatment, group 2: 31.25 mg /kg, group 3: 62.5mg/kg and group 4: 125 mg/kg (bw./day) boric acid (HBO ) was administered with drinking water for 5 weeks. At theend of the experiment, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) activities,glucose, total cholesterol, HDL-cholesterol, triglyceride, total protein, albumin, globulin, urea, creatinine, calcium (Ca),inorganic phosphorus (Pi), magnesium (Mg), sodium (Na), potassium (K), iron (Fe), copper (Cu), zinc (Zn), manganese(Mn), selenium (Se), chromium (Cr) and boron (B) levels were determined. Alkaline phosphatase enzyme activity(P<0.001) and Pi concentrations (P<0.001) in serum in all of the BA groups, Zn (P<0.05) and B (P<0.001)concentrations in 62.5 and 125 mg/kg (bw.) BA given groups were significantly higher. Other blood parameters werenot affected by BA. As a result, 31.25, 62.5 and 125 mg/kg (bw/day) boric acid increased serum ALP enzyme activity,Pi, Zn and B concentrations related to bone metabolism, but no effect on other enzymes and metabolites have beenidentified, therefore, further studies with different doses and different forms of B may be valuable in rabbits.