An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles
2018
S1 File. Figure A: Chronic inflammation in the test animals over the trial period. Figure B:
Acute inflammation in the test animals over the trial period. Figure C: Tissue necrosis in the
test animals over the trial period. Figure D: Fibrosis in the test animals over the trial period.
Figure E: Granulomatous/foreign body response in the test animals over the trial period.
Figure F: Representative TEMs of skin biopsies of particles group (A) and particles+MEFs
group (B) in the in vivo experiment injecting particles+MEFs. Particles could be identified in
skin biopsies of both the particles and particles+MEFs groups. The aim of the TEM investigation
was to determine if any cells could be detected inside the particles. No cells were present
inside the particles in either group. These results reflect the conclusion that was made after the
light microscopy study, indicating that cells did not migrate into the ported PCL particles. Bar
in A = 5μm and in B = 10μm.
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