Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study.

Jung Hun Lee,Masayuki Takahashi,Jeong Ho Jeon,Lin-Woo Kang,Mineaki Seki,Kwang Seung Park,Myoung-Ki Hong,Yoon Sik Park,Tae Yeong Kim,Asad Mustafa Karim,Jung Hyun Lee,Masayuki Nashimoto,Sang Hee Lee

Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study.

2019

Jung Hun Lee
Masayuki Takahashi
Jeong Ho Jeon
Lin-Woo Kang
Mineaki Seki
Kwang Seung Park
Myoung-Ki Hong
Yoon Sik Park
Tae Yeong Kim
Asad Mustafa Karim
Jung Hyun Lee
Masayuki Nashimoto
Sang Hee Lee

ABSTRACTResistance to β-lactams is one of the most serious problems associated with Gram-negative infections. β-Lactamases are able to hydrolyze β-lactams such as cephalosporins and/or carbapenems....

Keywords:

Genetics
Cephalosporin
Biology
Subclass
Antibiotic resistance
metallo β lactamase
Phylogenetic tree
Antibiotics

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