Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Dong Hou,Guangwei Xu,Caibo Zhang,Boxuan Li,Junchao Qin,Xiaohe Hao,Qiao Liu,Xiyu Zhang,Jinsong Liu,Jian-Jun Wei,Yaoqin Gong,Zhaojian Liu,Changshun Shao

Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

2017

Dong Hou
Guangwei Xu
Caibo Zhang
Boxuan Li
Junchao Qin
Xiaohe Hao
Qiao Liu
Xiyu Zhang
Jinsong Liu
Jian-Jun Wei
Yaoqin Gong
Zhaojian Liu
Changshun Shao

Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Keywords:

Molecular biology
Homologous recombination
Ovarian cancer
DNA damage
Poly ADP ribose polymerase
Biology
Berberine
Oxidative phosphorylation
PARP1
Cancer cell
PARP inhibitor
RAD51
Oxidative stress
Cell biology
DNA repair

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