Carboline compounds useful in the treatment of neurodegenerative diseases
2014
A compound according to formula (A) ** ** Formula or a salt, solvate, clathrate, hydrate or pharmaceutically acceptable polymorph thereof, wherein X and Y are different and are selected from: CH2 and ** Formula ** in which - n and m are independently selected from 2 and 3; - R2 and R3 are selected independently from each other from the groups consisting of: - alkyl (C1-C12) alkyl; (C2-C12) linear or branched; (C2-C12) linear or branched; said alkyl, alkenyl or alkynyl group may be substituted, with at least one substituent selected from halogen, cycloalkyl, hydroxy, alkoxy, amino, acylamino, aroylamino, heteroaroylamino and carboxy; - heteroaroylamino; - heterocycloalkyl (C2-C6) cycle comprising an oxygen atom and / or a nitrogen atom; - benzyl optionally substituted with an alkyl group, halogen, an ether group and / or an amino group; or R2 and R3 form together with the nitrogen atom a heterocycle that transports (C2-C7) saturated or unsaturated; R4 is selected from F, Cl, H, O-CH3, and -CH3; R5 is selected from H, CH3 and phenyl; with the proviso that R5 is not H if X is CH2.
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