In vitro studies on the lymphoma growth-inhibitory activity of sulfasalazine

Sulfasalazine (SASP) is a novel, potent inhibitor of cellular cystine uptake mediated by the xc− cystine/glutamate antiporter. Lymphoid cells cannot synthesize cyst(e)ine and depend for growth on its uptake from their micro-environment. We previously showed that SASP (0.2 mM) can abrogate lymphoma c