Chemical constituents of Litsea elliptica and their alpha-glucosidase inhibition with molecular docking

Background: Litsea elliptica (LE) is an edible plant in Thailand, which has been used as vegetables, flavoring materials, and traditional herbal medicine. Some species of Litsea have been reported on anti-diabetic activity. However, LE has not been reported of chemical constituents and their alpha-glucosidase activity. Objectives: The aim was to study on chemical constituents and anti-diabetic activity through in vitro models of LE. Materials and Methods: Chromatographic and colorimetric enzyme methods with computer molecular docking were used in this research. Results: Anew quercetin-diglycoside (1) and six compounds (2-7) were isolated from LE which were elucidated as quercetin-3-O -α-rhamnopyranoside-O -(1→2)-α-apiofuranoside (1), quercetin-3-O -α-rhamnopyranoside (2), quercetin-3-O -β-glucopyranoside (3), uridine (4), isoboldine (5), reticuline (6) and β-sitosterol-D-glucopyranoside (7). Four isolated compounds exhibited anti-alpha glucosidase activity by inhibition concentration at 50% (μg/mL) values as 5 (243.25)