Quantitation of sodium mercaptoundecahydrododecaborate by capillary isotachophoresis

Abstract A simple, specific and accurate method for the quantitation of sodium mercaptoundecahydrododecaborate, which is a very hygroscopic agent for boron neutron-capture therapy, was developed by using capillary isotachophoresis with sodium p -toluenesulphonate as an internal standard. Compound 1a was separated and identified using 0.01 M hydrochloric acid and β-alanine as the leading electrolyte and 0.01 M n -caproic acid as the terminating electrolyte. It could be resolved well from the oxidation products, sodium sulphidobis (undecahydrododecarborate) and sodium sulphidobis (undecahydrododecarborate) S-oxie, and the detection limit was 0.7 μmol/ml.