Diastereoselective Enzymatic Synthesis of Highly Substituted 3,4-Dihydropyridin-2-ones via Domino Knoevenagel Condensation—Michael Addition—Intramolecular Cyclization
2012
Abstract A direct method to construct 3,4-dihydropyridin-2-ones by enzymatic condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds was developed. One ring and four new bonds (two C–C, one C–N, one C C) were formed in one pot. And reaction conditions involving hydrolases, solvents, substrate molar ratios, and hydrolase loading were optimized. A series of new compounds based on the 3,4-dihydropyridin-2-one core were synthesized by the unprecedented three-component domino reaction.
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