The novel zinc(II) complex with dibromo substituted Schiff base and its biological activity

Abstract Schiff base 3,5-dibromo-N-(8-quinolyl)salicylaldimine (HqsalBr2) and its zinc(II) complex, [Zn(qsalBr2)2], have been synthesized and characterized using spectroscopic techniques and single crystal X-Ray crystallography. The interaction of the complex with calf thymus DNA (CT-DNA) was investigated by electronic absorption and luminescence titration methods. The results reveal the intercalative mode of binding between the synthesized complex and CT-DNA with binding constant (Kb) of 2.00 × 106 M-1. The complex also exhibits capability in the competitive reaction with the standard ethidium bromide (EB) and provides favourable quenching constant value (Kq) of 7.91 × 1011 M-1s-1. Anti-lung cancer activity against A549 cell line was examined and zinc(II) complex performed the ability in the inhibition of this cancer cell growing.