Enterotoxigenic Escherichia coli Heat-Labile Toxin Derived from Dose of Recombinant Double Mutant Safety and Immunogenicity of a Single Oral

(ETEC) is a primary cause of traveler’s diarrhea for which there is no licensed vaccine. Thisphase 1 trial determined the safety and immunogenicity of a recombinantly produced double mutant heat-labile enterotoxin(dmLT) of ETEC. It was administered as a single oral dose of dmLT in escalating doses of 5