A new simple and convenient method for preparation of oligonucleotides containing a pyrene or a cholesterol moiety
2015
A new simple and convenient approach to the synthesis of oligonucleotides containing pyrene or cholesterol moieties is described. The approach does not require a special phosphoramidite reagent as it is based on Staudinger reaction between an azidoalkyl derivative of either pyrene or cholesterol and a polymer-supported internucleoside 2-cyanoethyl phosphite, which is formed during phosphoramidite condensation.
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