Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, 1H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated.