Somatic Mutation in Immunoglobulin Gene Variable Region in Patients with Chronic Lymphoid Leukemia and its Influence on Patients' Prognosis in Irany

Results: Patients were in an age range of 42 to 80, with their mean age being 62 (SE=1.87) and 73% of them being male. Their mean WBC count, lymphocytes percentage, average hemoglobin level and platelet count were, respectively, 56000/microliter, 85%, 12 gr/ dl and 150000/microliter. According to their molecular analysis, 38.9% of patients were unmutated and 61.1% showed mutation in the variable heavy chain locus. The most common mutation had occurred in the IGVH3 allele (66.66%). The mean overall survival rate of patients, mutated and unmutated, was, respectively, 39 (95%CI 32, 46) and 31 (95%CI 26, 36) months (P=0.407).Benet stage had statistically meaningful relation to patients survival (p=0.02) . Discussion: Similar to the findings of other studies, IGVH3 mutations were found to be prevalent by this study too. Although a correlation was found to exist between the patients’ survival and IGVH mutation, it was not statistically significant due to the limited number of the patients. We can conclude that clinical methods are still valuable in determining the prognosis of patients with CLL today.