Benzoxa- and benzotiazolil sulfamatos and its use as inhibitors of sulfatase steroid.
2000
A compound of formula I ** (Formula) ** wherein X is O or S; R1 and R2 are independently hydrogen or alkyl, or one of them is hydrogen and the other is acyl or alkoxycarbonyl; and R3 is alkyl; alkenyl, alkynyl; cycloalkyl selected from adamantyl and hexahydro-2,5-methanopentalenyl; c-chloalkenyl; aryl; cycloalkylalkyl selected from adamantylalkyl of 1 to 4 carbon atoms in its part alkylene and dicyclohexylmethyl; cycloalkylalkenyl (including cycloalkanylidenalkyl) selected from adamantanylidenalkyl (C1-4), cycloalkylidene (C4-12) alkyl (C1-4), bicyclo [3.3.1] nonylidenemethyl, dimethylcyclohexylmethyl, alkoxy (C1-4) cyclohexylidenemethyl, alkyl (C1-4 ) cyclohexylidenemethyl, tetraalkyl (C1-4) cyclohexylidenemethyl, 1,4-dioxaespiro [4.5] dec-8-ylidenemethyl, 3, 3-dimethyl-1, 5-dioxaespiro [5.5] undec9-ylidenemethyl and octahydronaphthanylidemethyl; cycloalkenyl alkyl; arylalkyl; arylalkenyl; arylalkyl; alkoxycarbonylaminoalkyl; hydroxycycloalkylalkyl; cycloalkylidenecycloalkanylidenalkyl; heteroaryl; or heteroarylalkyl; in free form or in salt form.
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