Method for screening and / or evaluation of the efficacy of drugs for the treatment of mitochondrial diseases and MELAS syndrome

The present invention relates to a method for identifying and evaluating the efficacy of drugs for the treatment of diseases involving mitochondrial dysfunction and / or MELAS, a model Saccharomyces mutant cerevisiae A14G and fibroblasts derived from patients MELAS syndrome MELAS and cybrids transmitocondriales.