Palladium-Catalyzed Isomerization-Coupling Reactions of Allyl Chloride with Amines to Generate Functionalized Phosphorus Derivatives

A Pd-catalyzed isomerization-coupling reaction of P-containing allyl chloride with amine afforded imine or enamine that was converted to various functionalized phosphorus derivatives via hydrolysis, reduction, or Stork reactions. The reaction was confirmed to proceed via an isomerization of a starting material and a coupling of the resulting vinyl chloride with amine.