An Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)-γ-Rubromycin†
2009
(1, Scheme 1), the prototypical member of astructurally related family of antibiotics known as therubromycins, consists of a densely oxygenated naphthazarinring and an isocoumarin moiety linked through a uniquearomatic 5,6-spiroketal ring system (Scheme 1). The rubro-mycins exhibit a wide range of biological activity includingantimicrobialandanticancerproperties.
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