The Neurocircuitry of PTSD and Major Depression: Insights into Overlapping and Distinct Circuit Dysfunction - A Tribute to Ron Duman

Abstract The neurocircuitry that contributes to the pathophysiology of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), psychiatric conditions that exhibit a high degree of comorbidity, likely involves both overlapping and unique structural and functional changes within multiple limbic brain regions. In this review, we discuss neurobiological alterations that are associated with PTSD and MDD, and highlight both similarities and differences that may exist between these disorders to argue for the existence of a shared neurobiology. We highlight the key contributions based on preclinical studies, emerging from the late Professor Ronald Duman’s research, that have shaped our understanding of the neurocircuitry that contributes to both the etiopathology and treatment of MDD and PTSD.