Antagonists nonpeptide receptor glp-1 and methods of use.

A compound of formula: ** (Formula) ** wherein R 1 is a phenyl or pyridyl group, optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, nitro, trifluoromethyl, cyano, C1-C6 alkyl, C2-C6 and C1-C6alkoxy; R2 is: where r, is: hydrogen; a hydroxy group; -OR5, where R5 is a C1-C6 alkyl or alkenyl group optionally substituted with C2C6 hydroxy group or an amino group, C1-C6 alkoxy, cycloalkyl, thioether, heterocycloalkyl, aryl or heteroaryl, optionally substituted with one or more independently selected from the group consisting of substituent groups alkyl, hydroxyalkyl, carboxyl, C1-C6 alkoxycarbonyl, oxygen, halogen and trifluoromethyl; or -NR6R7, wherein R6 and R7 are each independently hydrogen or an alkyl group C1-C6 alkyl, C2-C6, amino or imino, optionally substituted with a hydroxy group, a C1-C6 alkyl or an amino, thioether , heterocycloalkyl, aryl or heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of oxygen, halogen, trifluoromethyl and carboxyl, or wherein -NR6R7 forms a heterocyclic ring of 5 or 6 members optionally containing, in addition to the nitrogen heteroatom, a heteroatom selected from the group consisting of O, N and S; - (CH2) nOR?, wherein n is 1 or 2, and r, it is hydrogen, a C5-C7 heteroaryl group or where R8 is hydrogen, a C1-C6, cycloalkyl C3-C6 group or a 5- or 6-membered optionally substituted with one or more substituents independently selected from the group consisting of halogen, methyl and trifluoromethyl; - (CH2) pN (rd) (R??), wherein p is 1 or 2, r, is as defined above and R?? is hydrogen or an alkyl or alkoxy group optionally substituted by a C3 C6 alkyl optionally substituted with cyano; -CH = NR??, wherein R?? is hydrogen, hydroxy or -OR 9 group wherein R 9 is an alkyl, cycloalkyl, aryl or heteroaryl; or a heterocyclic ring of 5 or 6 members containing one to three heteroatoms independently selected from the group consisting of O, N and S, the ring being optionally substituted with one or two substituents independently selected from the group consisting of methyl groups being, methoxymethyl, oxygen, and C1-6 alkoxy; R3 is hydrogen or a C1-C6 alkyl, C2-C6 or (C1-C3 alkoxy) C1-C3.