Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

A. Theron,Robyn Roth,Heinrich C. Hoppe,Christopher J. Parkinson,C. W. van der Westhuyzen,Stoyan Stoychev,Ian Wiid,Ray-Dean Pietersen,Bienyameen Baker,C. P. Kenyon

Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

2017

A. Theron
Robyn Roth
Heinrich C. Hoppe
Christopher J. Parkinson
C. W. van der Westhuyzen
Stoyan Stoychev
Ian Wiid
Ray-Dean Pietersen
Bienyameen Baker
C. P. Kenyon

CITATION: Theron, A., et al. 2017. Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform. PLoS ONE, 12(10):e0185068, doi:10.1371/journal.pone.0185068.

Keywords:

Tuberculosis chemotherapy
Mycobacterium tuberculosis
Microbiology
Drug discovery
Pharmacology
Multiple drug resistance
Biology
Tuberculosis
Glutamine synthetase
Adenosine monophosphate
Glutamine
Escherichia coli
Intracellular
Adenylylation
Enzyme
Biochemistry
Chemistry

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