Method of estimating the biological age of skin by means of a fluorescence multispectral video dermatoscope

A method is proposed for evaluating age changes of the skin, based on an analysis of images obtained by means of the EcoSkin fluorescence dermatoscope. Parameters calculated by multiple regression analysis that combine information on aging at the molecular and morphological levels serve as integral markers of age changes of the skin. Measurements on sections of the skin subjected to solar action or protected from it make it possible to evaluate the photoage and bioage of the skin separately. Measurements of the corresponding parameters in seventy women with skin phototypes II and III, aged from 13to93years, provided correlation coefficients of 0.83-0.87 with calendar age. When age according to the person's external appearance was taken into account, these coefficients increased to 0.92-0.94.