Substituted benzenesulfonylurea and-thiourea, their preparation and their use for producing pharmaceutical preparation and medicament containing them

PROBLEM TO BE SOLVED: To obtain novel substituted benzenesulfonyl(thio)urea useful for the treatments of heart diseases such as cardiac arrhythmia, ischemic diseases, etc. SOLUTION: This substituted benzenesulfonyl(thio) urea is expressed by formula I {R(1) is H, a 1-6C alkyl or cycloalkyl; R(2) is a 1-6C alkyl, a 1-6C alkoxy, a 1-6C mercapto alkyl or the like; R(3) and R(4) are each H, a 1-6C alkyl, together form a (CH 2 ) 2-5 chain.; E and X are each O or S; Y is a carbon chain of the formula [CR(5) 2 ] m [R(5) is H or a 1-2C alkyl; (m) is 1 or 2]; Ar is phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl, pyridyl or the like}, e.g. N-5-(1-phenylethyl)aminocarbonylmethyl-2-methoxyphenylsulfonyl-N'- methylthiourea. The compound of formula I is obtained by reacting, e.g. an aromatic sulfonamide of formula II with a substituted isocyanate of the formula R(1)-NCO. COPYRIGHT: (C)1996,JPO