Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation
2001
Here we have reviewed the conventional definitions and fundamental
characteristics of the two basic types of stem cells, embryonic
stem cells (ESCs) and somatic stem cells (SSCs). By taking into
account the often-overlooked asymmetric cell kinetics of SSCs, we
consider the evidence that should SSCs retain these growth
kinetics in vitro, a natural kinetic barrier to SSC propagation
exists. Recent discoveries showing that the tumor suppressor gene
p53 can act as a regulator of asymmetric cell kinetics provide a
target pathway for in vitro SSC propagation strategies.
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