Contributions of Lorente de Nó to the Nonlinear Circuitry of the Brain

Rafael Lorente de No, the youngest disciple of Santiago Ramon y Cajal, made significant and versatile contributions to the broad area of neuroscience. Present assay highlights the groundbreaking contributions of this Spanish investigator to neuronal connectivity. From Lorente de No laws of plurality and recurrence of connections among neurons emerged nonlinear connectivity and, therefore, set the foundation to understand the emergent properties of neuronal circuits. The emergence, truthfulness, and applicability of these organizing principles are discussed in the context of their current impact in studying neuronal ensembles. Anat Rec, 303:1215-1220, 2020. (c) 2019 American Association for Anatomy.