Bis-naphthalimides. 2. Synthesis and biological activity of 5,6-acenaphthalimidoalkyl-1,8-naphthalimidoalkyl amines
1995
Summary A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enhances aqueous solubility, we found that these compounds were no more soluble or cytotoxic than the homologous symmetric series.
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