Clock gene and hyaluronic acid synthase gene expression promoter

A promoting more effective expression of clock genes and hyaluronic acid synthase gene in the skin. 1 and one or two kinds selected from A lavender oil and eucalyptus oil, a composition containing the alkylene oxide derivative represented by the following general formula (I) is applied to the skin. (Wherein, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and n are each an oxyalkylene group having 3 to 4 carbon atoms, an average addition mole number of oxyethylene groups, 1 ≦ m ≦ 70,1 a ≦ n ≦ 70, the ratio of oxyethylene groups to the total of oxyalkylene groups and oxyethylene groups is 20 to 80 wt%. oxyalkylene group and oxyethylene group is not added to the block-shaped also good .R